CORRELATION OF TWO PYRAZOLINE MOIETY IN A SINGLE MOLECULE VIA N-LINKAGE CONTAINING FLUORINE ATOM AS A SUBSTITUENT AND THEIR BIOLOGICAL SIGNIFICANCE

Objective: The aim of the present invention is to synthesize and find out the biological importance of the series of the designed pyrazoline compounds. Methods: A series of 3-[3'-(2â€,4â€-dichloro-5â€-fluorophenyl)-5'-(2â€-furyl)-4', 5'-dihydro-1H-pyrazol-1'-yl]-5-substituted phenyl-2-pyrazolines (2a-j) and 1-Nitroso-3-[3'-(2â€,4â€-dichloro-5â€-fluorophenyl)-5'-(2â€-furyl)-4', 5'-dihydro-1H-pyrazol-1'-yl]-5-substituted phenyl-2-pyrazolines (3a-j) were prepared in moderate yields. The structures of both pyrazoline and N-nitroso pyrazoline derivatives have been characterized on the basis of physical properties of the molecule and satisfactory spectral (IR, 1H NMR) data. The antimicrobial activity of the compounds against some Gram (+) and Gram (–) bacteria is reported. Results: The Moderate yield of the proposed compounds was obtained. Spectral analysis showed the structural confirmation of the synthesized compounds. Some of the compounds showed lower to moderate level of drug-like properties. Conclusion: From the results of spectral data and microbial activity it has been concluded that the compounds were found to exhibit some functional lead properties; hence these compounds are worth to be considered as potential lead molecules for further study